“Birdhouse In Your Soul,” a 1989 single from the always-quirky They Might Be Giants, reached #3 on the US Modern Rock Tracks Chart, performed well on college radio, and has been the alternative rock band’s best-performing release to date. The tune bounces back and forth between C major and Eb major throughout (starting at 0:27), with the exception of an early instrumental bridge from 1:24 – 1:43, which plays by its own rulebook.
Also stranger than fiction: the tune was later covered by Broadway stars Kristin Chenoweth and Ellen Greene for the TV series Pushing Daisies (see second video below).